First baby born after deceased womb transplant

Ebony Scott
December 7, 2018

But in the Brazilian woman's groundbreaking case, her new uterus was actually donated from a deceased donor, then used to successfully conceive and carry the child born past year.

The 10-hour transplant operation - and later fertility treatment - took place in São Paulo, Brazil, in 2016.

Aside from relying on a deceased donor for their uterine transplant, the doctors might have also made the procedure less costly and unsafe.

Singer stressed that pregnancies involving transplanted uteruses from deceased donors have failed in the past, but the Brazilian case is "an exciting step in the right direction".

The study is also the first uterine transplantation in Latin America.

It said the case involved connecting veins from the donor's uterus with the recipient's veins, as well as linking arteries, ligaments, and vaginal canals.

The transplanted uterus was also removed during the cesarean section and showed no anomalies, the doctors noted.

With this recent success comes not just the promise of greater access to donor organs, but vital information on what a transplanted uterus requires to successfully carry an embryo to full term.

The donated uterus was removed during the C-section and the woman's wound healed well, the researchers say.

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IVF Australia medical director Associate Professor Peter Illingworth said using deceased donors avoided the need for women to undergo major surgery and the risk of complications in order to donate their uterus to their loved one.

In 2016, doctors at the Cleveland Clinic in OH transplanted a uterus from a deceased donor, but it failed after an infection developed. The baby girl was born via caesarean section at 35 weeks and three days, and weighed nearly 3 kgs.

Uterine transplants from living donors have occurred before.

Research leader Dr Dani Ejzenberg, of University of Sao Paulo in Brazil, said: "The use of deceased donors could greatly broaden access to this treatment.for women with uterine infertility". Those transplants can only be done for women who find a donor, who must undergo a complicated surgery and lengthy recovery, Dr. Tullius said.

While researchers in countries including Sweden and the U.S. have previously succeeded in transplanting wombs from living donors into women who have gone on to give birth, experts said the latest development was a significant advance.

Her fertilised eggs were implanted after seven months - and 10 days after implantation, the recipient was confirmed to be pregnant.

There have been a total of 39 live donor transplants, resulting in 11 live births in the past five years.

"Uterine transplantation can help many couples in achieving their dream of parenthood", he said, and "using a uterus from a deceased organ donor increases the number of donors available significantly".

The mother and baby were discharged from the hospital three days after birth. When the researchers wrote the paper describing the case - about seven months after the birth - both mom and the baby girl were healthy. For future procedures he hopes to cut down on the time to transplant by removing the uterus before other organs, like the heart and kidneys. Within this group about one in 500 women have irreversible infertility - which can be due to a congenital malformation, cancer, or other illness, leading to genetic absence or removal of the uterus.

Other reports by GizPress

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